Sildenafil - The active ingredient in Zenegra

Zenegra is the generic name for the popular brand name "blue pill", Viagra, used for treating symptoms of Erectile Dysfunction (or ED). Both Viagra and Zenegra contain the same active ingredient Sildenafil Citrate, which is a class of drugs called phosphodiesterase-5 (PDE5) inhibitors. PDE5 inhibitors are the driving force behind all drugs that are prescribed for ED-related treatments.

How does Sildenafil work?

Sildenafil-molecularIt is believed that over 140m men worldwide suffer from ED or related sexual dysfunctions. Usually, sexual stimulation results in the secretion of a chemical called Nitric Oxide into the penis. It is this chemical that's responsible for activating an enzyme known as guanylate cyclise, which triggers the production of cyclic guanosine monophosphate (cGMP) in the body. As the key ingredient responsible for regulating the flow of blood to the penile region, cGMP is what encourages (or discourages) a man's erection.

In order to perform satisfactory sex, men need a penis that is erect before, during and shortly after sexual acts. This erection is a result of sexual stimulation, which causes the brain to send signals to the muscles in a man's penis to pump more blood to the penile blood vessels. Increased penile region blood flow translates into an erection.

Sometimes though, the blood flow to a man's penis is restricted. The causes for such condition may be physical or psychogenic, either causing a man's penis not to respond to sexual stimulation, or making it more difficult for him to sustain an erection long enough for sexual activity.

Sildenafil Citrate, which is the main ingredient in Zenegra, is instrumental in helping to inhibit the PDE5 enzyme, which is the main cause for destroying the erection enabling cGMP in a man's penile region. By allowing cGMP to persist for an extended period in the blood stream, Sildenafil Citrate facilitates the engorgement (hardening) of the penis to last longer. This allows men to perform and enjoy sexual activity for a longer period.

Making the right choice

Sildenafil based drugs are not just used for the treatment of ED alone, but for other conditions such as depression and other pulmonary conditions. Pharmacists and medical practitioners often review a patient's entire medical history before recommending the exact Sildenafil dosage that is most appropriate for their patient.

Zenegra, which has Sildenafil as its primary ingredient, is available in 100 mg and 50 mg versions. Making the right decision and choosing the most effective Zenegra for your unique requirements is important if you need effective management of your ED symptoms. And the best person to assist you with making the right choice is your pharmacist or health care professional.